Figure 3.
Single oral doses of dapagliflozin were demonstrated to stimulate an increase in urinary glucose excretion in Zucker diabetic fatty rats (A) over 6 hours, and (B) 24 hours post dose.
Notes: *P < 0.0001; †P < 0.05, each versus vehicle. Copyright © 2008. Reprinted with permission from American Diabetes Association. Han S, Hagan DL, Taylor JR, et al. Dapagliflozin, a selective SGLT2 inhibitor, improves glucose homeostasis in normal and diabetic rats. Diabetes. 2008;57(6):1723–1729.33
Abbreviation: BW, body weight.