Table 2:
Perioperative data
| Variables | Group I (n = 24) | Group II (n = 26) | Group III (n = 27) | P-value |
|---|---|---|---|---|
| Duration of intervention (min) | 310 ± 50* | 317 ± 68 | 361 ± 100 | 0.04 |
| Duration of CPB (min) | 88 ± 34 | 90 ± 26 | 102 ± 46 | 0.36 |
| Aortic clamp time (min) | 66 ± 39 | 67 ± 24 | 78 ± 31 | 0.26 |
| Heparin dose (UI/kg) | 513 ± 115 | 459 ± 97 | 540 ± 155 | 0.07 |
| Protamine dose (UI/kg) | 653 ± 168 | 712 ± 339 | 773 ± 203 | 0.22 |
| Crystalloids infusion (ml/kg) | 9.5 ± 4.2 | 9.5 ± 7.0 | 12.6 ± 8.7 | 0.19 |
| Hetastarchs infusion (ml/kg) | 5 (0–6)** | 6 (0–14) | 7 (1–10) | 0.03 |
| Red blood cells units | 0 (0–1)** | 1 (0–2) | 2 (0–3) | 0.03 |
| FFP units | 0 (0–0) | 0 (0–0) | 0 (0–3) | 0.23 |
| Platelets units | 0 (0–0) | 0 (0–0) | 0 (0–0) | 0.74 |
| Tranexamic acid use, n (%) | 15 (62) | 10 (38) | 16 (59) | 0.17 |
| Dose of tranexamic acid, mg/kg | 37.2 ± 9.0 | 33.0 ± 15.3 | 30 ± 11.2 | 0.24 |
| PCC use, n (%) | 6 (25) | 13 (50) | 11 (41) | 0.19 |
| Dose of PCC, UI/kg | 13.5 ± 8.2 | 12.5 ± 5.5 | 12.2 ± 5.8 | 0.90 |
| Catecholamine use, n (%) | 0 | 1 (4) | 4 (15) | 0.08 |
| Postoperative ACT (sec) | 131 ± 24 | 140 ± 18 | 135 ± 18 | 0.43 |
CPB: cardiopulmonary bypass; FFP: fresh frozen plasma; PCC: prothrombin complex concentrates; ACT: activated clotting time.
*P = 0.06 for group I vs group III.
**P = 0.004 for group I vs group III.