Table 2.

All Gag mutations associated with PI exposure and/or resistance and maturation inhibitor resistance

Gag mutation	Associated with PI exposure		Associated with PI resistance	Associated with maturation inhibitor resistance
	in vivo	in vitro
MA
E12K		yes [59,60]
G62R		yes [61]
L75R		yes [59,60]
R76K	yes [62,63]		yes [62]
Y79F	yes [62,63]		yes [62]
T81A	yes [62,63]		yes [62]
K112E		yes [64]
CS MA/CA
V128I/T/A/del	yes [56,65,66]	yes [64]	yes [64]
Y132F	yes [46,67]
CA
M200I		yes [64]
H219Q/P		yes [59,60,64]
CS CA/p2
A360V	yes [46]
V362I		yes [68]		yes [69,70]
L363M/F/C/N/Y		yes [61]		yes [69,71-74]
S368C/N		yes [51,54]		yes [69]
p2
Q369H	yes [54]			yes [72,74]
V370A/M/del	yes [54]			yes [69,70,72,74-76]
T371del	yes [77]			yes [72,74,76]
CS p2/NC
S373P/Q/T	yes [51,54,78]
A374P/S	yes [78]
T375N/S	yes [46,78]
I376V	yes [46,51]
G381S	yes [46]
NC
I389T	yes [77]
V390A/D		yes [59,60]
I401T/V	yes [77]	yes [64]
R409K		yes [59-61,64]
CS NC/p1
E428G	yes [66]
Q430R		yes [44]
A431V	yes [10,45,46,51,55,57,77-83]	yes [10,44,84,85]	yes [13,55,81]
K436E/R	yes [10,55,82]	yes [10]	yes [10,13,55]
I437T/V	yes [10,45,46,51,55,78,82,86]	yes [10,61]	yes [10,13,55]
CS p1/p6-gag
L449F/P/V	yes [9,45,46,55-57,67,77,79,80,82,86]	yes [44,49,85,87]	yes [55]
S451T/G/R	yes [55,66]
R452S/K	yes [55,66,79,82]	yes [87]	yes [55]
P453A/L/T	yes [9,55,57,77,81,82][67]	yes [84,87]	yes [9,55]
p6-gag
E468K		yes [59]
Q474L	yes [77]
A487S	yes [77]
P497L	yes [77]
p6-pol
V484G/I/P/S	yes [88]
CS TFP/p6pol
D437N	yes [56,64]