Fig. 3.

SK3 current recovers in N-ethylmaleimide (NEM) but not dynasore. A and B: Cell membrane capacitance (top) and whole cell SK3 current density (bottom) plotted against time of recording from cells dialyzed with 1 mM NEM (A) or bath treated with 50 μM dynasore (B). Horizontal bars denote the presence and washout of apamin from the bath. Numbers on the plot correspond to the representative current density traces shown in the inset. C: normalized averages of SK3 current density recovery from apamin block in the presence of NEM or dynasore. *Statistical significance (P < 0.05, ANOVA) compared with cells not treated with NEM.