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. Author manuscript; available in PMC: 2013 Sep 1.
Published in final edited form as: Dev Biol. 2012 Jun 27;369(1):32–42. doi: 10.1016/j.ydbio.2012.06.018

Figure 5. FOXA2 is sufficient for MFP and LFP induction in the spinal cord.

Figure 5

Boxed areas in A and B are magnified in A′ and B′, respectively. (A, A′) Unilateral SHH misexpression (right side) is sufficient to induce a SHH+ LFP (boxed area, A; A′), but fails to induce a SHH+/LMX1B+ MFP. (B, B′) FOXA2 misexpression (right side) in the spinal cord is sufficient to induce both the MFP and LFP (boxed area, B; B′), accompanied by a FP-like morphology. Note that unlike the control side (arrowheads, A, B) FOXA2 and SHH both suppress LMX1gB+ dorsal dI5 interneurons.