Table 1.

PZ-128 Does not Enhance Bleeding Time in Baboons

PZ-128 Dose	Baseline	1-2 h	P value
		Platelets (k/μL)
1 mg/kg, n=3	270 ± 39	258 ± 44	0.75
3 mg/kg, n=5	339 ± 74	334 ± 99	0.88
6 mg/kg, n=4	286 ± 96	294 ± 80	0.63
		Hematocrit (%)
1 mg/kg, n=3	39 ± 3	41 ± 3	0.25
3 mg/kg, n=4	36 ± 1	39 ± 2	0.13
6 mg/kg, n=4	36 ± 4	40 ± 4	0.13
		Bleeding time (min)
ASA+Clopidogrel, n=1	5.5	>20	-
1 mg/kg, n=3	2.8 ± 1.3	3.3 ± 1.2	0.50
3 mg/kg, n=5	4.4 ± 1.9	4.6± 1.5	1.0
6 mg/kg, n=3	4.0 ± 2.3	3.7 ± 1.6	0.59

Venous blood was collected from male baboons into PPACK anticoagulant (final concentration 100 μg/ml) at baseline and at 1-2 h after the start of the intravenous PZ-128 infusion (1 mg/kg over 15 min, 3 mg/kg over 30 min, or 6 mg/kg over 45 min). Platelet counts and hematocrit were measured using a micro-60 automated cell counter (Horiba ABX, Diagnostics, Montpellier, France). Template bleeding time (BT) (Surgicutt; ITC, Edison, NJ) was measured at baseline at either 1 or 2 h after the start of the PZ-128 infusion. Data are reported as Mean ± SD and P values were determined by Wilcoxon matched pairs signed rank test.