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. 2012 Jun 5;303(4):E464–E474. doi: 10.1152/ajpendo.00163.2012

Fig. 2.

Fig. 2.

Disruption of glucose-stimulated glucagon-like peptide-1 (GLP-1) secretion from small intestine of T1R3−/− and T1R2−/− mice. A–C: ELISA-based measurements of GLP-1 secretion from intestinal explants of duodenum (A), jejunum (B), and ileum (C) of T1R3+/+ (black) or T1R3−/− (white) mice upon stimulation with buffer (B), 250 mM glucose (G), 100 mM sucralose (S), or 500 mM fructose (F). D–F: ELISA-based measurements of GLP-1 secretion from intestinal explants of duodenum (D), jejunum (E), and ileum (F) of T1R2+/+ (black) or T1R2−/− (white) mice upon stimulation with buffer or 250 mM glucose. Each bar, n = 4 mice. Data are presented as means ± SE. *P < 0.01 vs. buffer for that genotype, except for comparison of buffer and glucose treatments in T1R2−/− ileum (F; P = 0.01).