Fig. 7.

Robust glucose-stimulated GLP-1 secretion in colon of Roux-en-Y gastric bypass (RYGB) rats. A: carbohydrate content of feces from ileum, colon, and rectum of sham (black) and RYGB (white) surgery rats. Each bar, n = 5 rats. *P < 0.01. B and C: ELISA-based measurements of GLP-1 secretion from intestinal explants of ileum (B) or colon (C) of sham (black) or RYGB (white) rats upon treatment with buffer or 250 mM glucose. Each bar, n = 5 rats. *P < 0.01 vs. buffer for that same surgical manipulation. #P < 0.01 vs. same stimulus in sham controls.