Fig. 6.

mEPC decay time for EDL muscles of 4-wk diabetic mice is less sensitive to phenserine tartrate (PT), a selective inhibitor of AChE, and more sensitive to phenethylcymserine tartrate (PEC), a selective inhibitor of butyrylcholinesterase. A: representative mEPCs recorded from EDL muscles of control and 4-wk diabetic mice before and after in vitro application of 5 μM PEC or 5 μM PT. B: histograms of mEPC decay time (mean ± SE) for EDL muscles of control and diabetic mice before and at 30 min after exposure to 5 μM PEC or 5 μM PT. PT significantly prolonged the 90–10% decay time for mEPCs of EDL muscle preparations from both control and diabetic mice. However, PT prolonged decay time by 164 and 110% for control and diabetic preparations, respectively. Additionally, prolongation of mEPC 90–10% decay time was more apparent for muscles of diabetic mice when PEC was used. Bars represent the mean + SE obtained from 4 to 5 end plates before and after PT or PEC for each of 4 muscles from different mice. ***P < 0.01 compared with control; #P < 0.05 for the difference in decay time between control + PT and diabetic + PT. ###P < 0.01 for the difference in decay time between control + PEC and diabetic + PEC.