Fig. 8.

Immunofluorescence for HA-binding protein (red) shows increased regional expression of HA in small intestine and colon of wild-type (control) mice treated with exogenous HA. A and B: small intestine (PJ). Most HA in control mice is restricted to the crypt zone in the lamina propria and the muscularis layer (A), but in mice receiving HA intraperitoneally twice a week for 5 wk, HA expression extends into the lamina propria of the villi (B). C and D: DC. In control mice, HA expression occurs in a scattered pattern in the lamina propria between crypts (C), but HA has a more extensive coverage throughout the colonic lamina propria in mice treated with exogenous HA (D). Original magnification ×200.