Fig. 8.
TRAM-34 has no effect on the amplitude of the EFS-induced contractions in human DSM isolated strips. A: original recordings illustrating the lack of TRAM-34 (30 μM) effect on EFS-induced (0.5–50 Hz) contractions. B: frequency-response curves showing no significant change in the amplitude of the EFS-induced contractions following application of TRAM-34 (30 μM). The maximal EFS-contraction amplitude at a stimulation frequency of 50 Hz under control conditions was taken to be 100% and the contractions were normalized. Values are means ± SE (n = 21, N = 7; P > 0.05).