Fig. 1.

Maternal heart rate (in beats/min, left) and mean arterial pressure (in mmHg, right) on gestational day (GD) 118 (top) and 132 (bottom) experimental days in response to saline [pair-fed control (PFC)] and 1.75 g/kg ethanol doses in sheep. Alcohol was intravenously delivered to ewes beginning on GD 109 for 1 h on 3 consecutive days each week followed by 4 days without exposure, and the pattern was repeated till GD 132. For clarity, the 0.75-, 1.25-, and 1.5-dose plots were not presented but fell between the PFC and 1.75-dose groups in a dose-dependent manner. Maternal heart rate on GD 118 and GD 132 were significantly higher in all ethanol treatment groups compared with PFC. Maternal mean arterial pressure was progressively higher with increasing doses of ethanol on both GD 118 and 132. All values are means + SE. Adapted with permission from Cudd et al. (17).