Table 2.
Hemodynamic and limb vascular responses to 8 wk of fish oil or placebo in prehypertensive humans
| Fish Oil (n = 15) |
Placebo (n = 14) |
|||||
|---|---|---|---|---|---|---|
| Variable | Pre | Post | Pre | Post | Time | Time × Drug Interaction |
| Sex (male/female) | 15/0 | – | 13/1 | – | – | – |
| Age, yr | 23 ± 1 | – | 25 ± 3 | – | – | – |
| Height, cm | 179 ± 2 | – | 179 ± 2 | – | – | – |
| Body mass, kg | 88 ± 4 | 89 ± 3 | 87 ± 2 | 87 ± 2 | 0.71 | 0.71 |
| BMI, kg/m2 | 28 ± 1 | 28 ± 1 | 27 ± 1 | 27 ± 1 | 0.47 | 0.69 |
| SAP, mmHg | 127 ± 1 | 125 ± 2 | 126 ± 2 | 123 ± 2 | 0.04 | 0.59 |
| DAP, mmHg | 68 ± 2 | 68 ± 2 | 74 ± 2 | 74 ± 2 | 0.52 | 0.93 |
| MAP, mmHg | 88 ± 2 | 87 ± 1 | 92 ± 1 | 90 ± 2 | 0.22 | 0.79 |
| HR, beats/min | 73 ± 2 | 73 ± 2 | 76 ± 3 | 74 ± 3 | 0.26 | 0.53 |
| RRI, ms | 909 ± 34 | 941 ± 29 | 928 ± 34 | 941 ± 38 | 0.21 | 0.59 |
| RRISD, ms | 60 ± 5 | 75 ± 8* | 79 ± 12 | 80 ± 12 | 0.08 | 0.04 |
| FBF, ml·100 ml tissue−1·min−1 | 3.9 ± 0 | 3.5 ± 0 | 3.2 ± 0 | 3.4 ± 1 | 0.80 | 0.37 |
| FVC, 100 * ml·100 ml tissue−1·min−1·mmHg−1 | 4.5 ± 0 | 4.1 ± 0 | 3.5 ± 0 | 3.7 ± 1 | 0.75 | 0.49 |
| CBF, ml·100 ml tissue−1·min−1 | 2.8 ± 0 | 3.0 ± 0 | 2.4 ± 0 | 2.5 ± 0 | 0.48 | 0.82 |
| CVC, 100 * ml·100 ml tissue−1·min−1·mmHg−1 | 3.3 ± 0 | 3.5 ± 0 | 2.6 ± 0 | 2.7 ± 0 | 0.46 | 0.76 |
Values are means ± SE. Forearm vascular measurements: n = 14 fish oil and n = 13 placebo; calf vascular measurements: n = 14 fish oil and n = 11 placebo.
*
Significantly different from corresponding Pre value (P < 0.05, post hoc analysis).