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. 2012 Jun 15;303(4):H475–H485. doi: 10.1152/ajpheart.00238.2012

Fig. 7.

Fig. 7.

Decreased systolic heart function in Bmal1−/− mice. Wet heart weight (in mg) normalized to BW (in g) was significantly higher in Bmal1−/− mice compared with the WT group (A). The functional measurements of ex vivo working heart at preload of 10 mmHg and afterload of 55 mmHg with heart rate paced at 480 beats/min detected that Bmal1−/− hearts had deceased stroke volume (B), lower maximum left ventricular pressure (LVPmax; C), and slower systolic velocity (+dP/dt; D) compared with the WT group. No changes were found in diastolic velocity (−dP/dt; D) or end-diastolic left ventricular pressure (LVPmin; C). Values are means ± SE; n = 4 WT and 5 Bmal1−/− mice. *P < 0.05 and ***P < 0.001 compared with WT in Student's t-test.