Fig. 3.

Reverse remodeling at cellular/subcellular levels. Cardiomyocyte cytosolic free Ca²⁺ ([Ca²⁺]_i; top left) and mitochondrial free Ca²⁺ ([Ca²⁺ ]_m; bottom left) are each increased at 4-wk ALDOST but recover to control levels after 4-wk Recov. Cardiac mitochondrial Ca²⁺ overloading is accompanied by evidence of oxidative stress with increased H₂O₂ production by these organelles, which returns to controls levels with 4-wk Recov. Evidence of lipid peroxidative and 8-isoprostane content is seen in the gastrocnemius muscle at 4-wk ALDOST and then resolves with 4-wk Recov. *P < 0.05 vs. controls; †P < 0.05 vs. ALDOST.