Figure 6.

Mean paclitaxel concentration in tumor, lungs, heart, spleen, liver, and kidneys of mice treated with free PTX, CL-PTX, and TL-PTX. Mice were sacrificed at the indicated time points of (A) 0.5, (B) 1, (C) 3, (D) 5, (E) 12, and (F) 24 hours after administration, and paclitaxel was extracted from the tissues and measured by ultraperformance liquid chromatography.

Notes: There were five mice per group per time point. Bars represent the mean ± standard deviation.

Abbreviations: CL-PTX, paclitaxel-loaded conventional liposomes; TL-PTX, paclitaxel-loaded targeted PEGylated liposomes; Free PTX, paclitaxel dissolved in Cremophor EL.