Table 2.
Stability of formulated liposomes (mean ± SD, n = 3)
| Formulation | Parameters | Day | |||
|---|---|---|---|---|---|
|
|
|||||
| 0 | 1 | 3 | 7 | ||
| CL-PTX | Size (nm) | 137.3 ± 23.1 | 138.1 ± 24.2 | 137.5 ± 23.6 | 138.1 ± 25.1 |
| Zeta potential (mV) | 9.20 ± 0.31 | 9.24 ± 0.35 | 9.18 ± 0.29 | 9.25 ± 0.37 | |
| Encapsulation efficiency (%) | 89.7 ± 3.6 | 89.4 ± 3.2 | 88.9 ± 2.8 | 89.1 ± 3.0 | |
| TL-PTX | Size (nm) | 142.3 ± 46.4 | 142.6 ± 46.8 | 144.1 ± 47.2 | 143.6 ± 46.9 |
| Zeta potential (mV) | 5.05 ± 0.16 | 5.13 ± 0.19 | 4.98 ± 0.12 | 5.02 ± 0.18 | |
| Encapsulation efficiency (%) | 89.1 ± 2.3 | 89.3 ± 2.5 | 88.7 ± 1.8 | 88.9 ± 2.1 | |
Abbreviations: CL-PTX, paclitaxel-loaded conventional liposomes; TL-PTX, paclitaxel-loaded targeted PEGylated liposomes; SD, standard deviation.