Table 1.

Blood gas parameters

			Fraction of Inspired O2
	Baseline		Norm (21% O2)	Hyp10 (10% O2)	Hyp5 (5% O2)
Hct, %	49.1 ± 1.2	5HMF	48.8 ± 0.7	48.4 ± 0.8	47.9 ± 0.7
		Vehicle	49.4 ± 0.9	48.8 ± 0.7	48.4 ± 0.6
Hb, g/dl	14.7 ± 0.8	5HMF	14.6 ± 1.0	14.4 ± 0.8	14.1 ± 0.6
		Vehicle	14.9 ± 0.9	14.6 ± 0.8	14.2 ± 0.7
Po2, mmHg	56.8 ± 4.6	5HMF	63.1 ± 7.2	30.2 ± 4.7†‡	24.6 ± 4.4†‡§
		Vehicle	62.3 ± 5.9	28.8 ± 4.8†‡	18.7 ± 3.5†‡§
Pco2, mmHg	50.1 ± 5.4	5HMF	48.7 ± 4.9	33.6 ± 5.1†‡	27.6 ± 3.6†‡§
		Vehicle	49.5 ± 5.3	32.5 ± 4.2†‡	24.5 ± 4.1†‡§
pH	7.331 ± 0.028	5HMF	7.335 ± 0.029	7.328 ± 0.026	7.316 ± 0.017†‡§
		Vehicle	7.337 ± 0.024	7.319 ± 0.020	7.295 ± 0.016†‡§
BE, mmol/l	2.6 ± 1.8	5HMF	1.5 ± 1.9	−2.4 ± 2.1†‡	−5.6 ± 1.8†‡§
		Vehicle	2.4 ± 1.3	−2.6 ± 1.8†‡	−7.7 ± 1.5†‡§

Values are means ± SD. Baseline included all the animals in the study. No significant differences were detected at baseline between groups, before treatment. Norm, normoxia; Hyp10, 10% O₂ hypoxia; and Hyp5, 5% O₂ hypoxia; Hct, systemic hematocrit; Hb, hemoglobin; Po₂, arterial partial O₂ pressure; Pco₂, arterial partial pressure of CO₂; BE, base excess; 5HMF, 5-hydroxymethyl-2-furfural. P < 0.05 compared with baseline (

^†), compared with normoxia (

^‡), and compared with 10% O₂ hypoxia (

^§).