Table 1.

Left ventricular invasive hemodynamics by pressure-volume conductance catheters in WT and Akita mice at 5 mo and 12 mo of age

	5 mo		12 mo
Hemodynamics	WT (n = 5)	Akita (n = 7)	WT (n = 4)	Akita (n = 4)
Pes, mmHg	87.1 ± 5.9	94.2 ± 6.8	91.2 ± 13.1	100.3 ± 8.1
Ped, mmHg	5.1 ± 1.1	4.8 ± 1.3	7.6 ± 3.5	6.0 ± 3.0
dPmax, mmHg/s	6,091 ± 617	9,111 ± 978‡	4,474 ± 152	5,180 ± 392*
dPmin, mmHg/s	−4,777 ± 998	−5,008 ± 1,001	−3,560 ± 185	−4,238 ± 401
RT, ms	16.0 ± 1.2	22.3 ± 2.1†	55.3 ± 7.1	51.0 ± 2.5
Tau, ms	4.21 ± 0.42	6.11 ± 0.22*	7.55 ± 1.5	6.34 ± 0.58
EDV, μl	40.9 ± 3.1	38.2 ± 5.3	54.3 ± 1.2	43.2 ± 1.8‡
ESV, μl	9.7 ± 2.6	6.7 ± 5.1	34.0 ± 9.1	19.3 ± 2.3*
SV, μl	29.9 ± 3.8	32.2 ± 4.1	29.6 ± 2.5	31.7 ± 2.9
CO, μl/min	15,299 ± 1,840	14,445 ± 2,001	14,825 ± 2,277	10,248 ± 325*
EF, %	75.7 ± 5.1	78.8 ± 10.1	54.3 ± 5.6	63.9 ± 3.0
SW, mmHg/μl	1958 ± 258	2133 ± 122	2309 ± 343	2513 ± 534
HR, beats/min	578 ± 31	554 ± 42	467 ± 37	385 ± 34*
Load-independent indexes
ESPVR	5.05 ± 0.33	8.12 ± 1.87*	3.49 ± 0.18	3.81 ± 0.70
EDPVR	0.11 ± 0.01	0.27 ± 0.09*	0.14 ± 0.01	0.18 ± 0.04
PRSW	89.6 ± 10.4	98.2 ± 16.7	71.68 ± 3.48	77.5 ± 11.34

Values are means ± SD. WT, wild type; Pes and Ped, end-systolic and -diastolic pressure; dP_max and dP_min, maximum and minimum changes in pressure; RT, relaxation time; EDV and ESV, end-diastolic and end-systolic volume; SV, stroke volume; CO, cardiac output; EF, ejection fraction; SW, stroke work; HR, heart rate; ESPVR and EDPVR, end-systolic and -diastolic pressure-volume relationship; PRSW, preload recruitable stroke work.

^*P < 0.05;

^†P < 0.01;

^‡P < 0.001.