Table 4.

Left ventricular invasive hemodynamics 7 days post-Ad.GFP or Ad.asNCX1 gene transfer in 20 wk WT or Akita mice

	WT + Ad.GFP	WT + Ad.asNCX1	Akita + Ad.GFP	Akita + Ad.asNCX1
Pes, mmHg	88.6 ± 3.4	99.9 ± 5.1*	102.0 ± 8.4	101.5 ± 9.7
Ped, mmHg	3.6 ± 0.5	5.2 ± 1.6	6.0 ± 3.1	4.8 ± 2.6
dPmax, mmHg/s	5,870 ± 400	6,864 ± 378	7,133 ± 188	7,331 ± 954
dPmin, mmHg/s	−3,664 ± 181	−4,932 ± 624	−4,864 ± 391	−5,605 ± 757
Tau, ms	4.96 ± 0.2	4.38 ± 0.50*	6.00 ± 0.2	5.25 ± 0.75
EDV, ul	41.6 ± 8.6	42.8 ± 8.2	44.7 ± 8.6	54.8 ± 9.78
ESV, ul	10.0 ± 2.4	9.6 ± 4.0	10.9 ± 2.4	22.1 ± 6.0†
SV, ul	25.0 ± 4.0	32.6 ± 5.2	38.8 ± 5.2	32.6 ± 8.5
CO, ul/min	11,951 ± 2,357	15,784 ± 1,613	16,788 ± 2,800	16,317 ± 1,613
EF, %	72.6 ± 8.2	79.8 ± 9.7	79.6 ± 3.2	59.8 ± 2.1‡
SW, mmHg/μl	1,533 ± 347	2614 ± 480	3,313 ± 470	2,722 ± 256*
ESPVR	4.78 ± 0.54	9.03 ± 2.47*	8.53 ± 2.44	3.07 ± 1.82‡
EDPVR	0.10 ± 0.01	0.13 ± 0.07	0.23 ± 0.03	0.30 ± 0.08‡
PRSW	80.1 ± 9.53	121 ± 27.22*	116.3 ± 11.1	93 ± 17.45
HR, beats/min	508 ± 26	538 ± 35	519 ± 26	489 ± 35

Values are means ± SD.

^*P < 0.05;

^†P < 0.01;

^‡P < 0.001.