Fig. 16.

Flash NanoPrecipitation schematic. Rapid mixing of the solvent and nonsolvent streams causes a drop in solvent quality and subsequent precipitation of the hydrophobic solutes. By matching the aggregation (t_agg) and nucleation and growth (t_ng) time scales (which are both larger than the mixing time scale t_mix), homogeneous nucleation kinetics result and polymer stabilized nanoparticles from 30 – 800 nm with narrow size distributions are produced. This scalable method allows for rapid, inexpensive, and versatile encapsulation of various hydrophobic molecules.^{146, 147}