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Effects of 8-OH-DPAT and CBD on specific binding of [3H]8-OH-DPAT to rat brainstem membranes (n= 6). The IC50 and Emax values of 8-OH-DPAT for its displacement of [3H]8-OH-DPAT, with 95% confidence limits shown in parentheses, were 9.6 nM (5.6 and 16.3 nM) and 96.6% (86.8 and 106.5%), respectively. Symbols represent mean values ± SEM.
