Figure 3.

Finasteride pretreatment reduces the seizure threshold elevation induced by midazolam. Finasteride (100 mg·kg⁻¹, i.p.) or vehicle was administered 5 min before the treatment with midazolam (500 µg·kg⁻¹, i.p.) or vehicle; 15 min after the second pretreatment, all animals were infused with PTZ. Bars indicate mean ± SEM of fractional threshold change values for tonic extension from 6–14 mice normalized with respect to the mean threshold value in the vehicle only control group, which was 59.2 ± 1.8 mg·kg⁻¹. In the absence of finasteride, midazolam caused a 2.3-fold increase in threshold (P < 0.001). Finasteride did not reduce the threshold significantly in the absence of midazolam (NS) but did reduce the threshold with midazolam pretreatment. *P < 0.001; one-way anova followed by Tukey's test.