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. 2012 Apr;165(8):2799–2807. doi: 10.1111/j.1476-5381.2011.01754.x

Figure 1.

Figure 1

GPR119 agonist AR231453 stimulates GLP-1 secretion from GLUTag cells both in the presence and in the absence of glucose, but insulin secretion from Min6 cells is stimulated by AR231453 only in the presence of glucose. (A) GLP-1 secretion from GLUTag cells in response to an eight-point dose titration of AR231453 (0–3 µM), in the presence or absence of 10 mM glucose. (B) Insulin secretion from Min6 cells in response to an eight-point dose titration of AR231453 (0–3 µM), in the presence or absence of 10 mM glucose. (C) GLP-1 secretion from GLUTag cells in response to an eight-point dose titration of glucose (0–25 mM), in the presence or absence of 3 µM AR231453. (D) Insulin secretion from Min6 cells in response to an eight-point dose titration of glucose (0–25 mM), in the presence or absence of 3 µM AR231453. The dose curves were generated with the log (agonist) versus response (three parameters) algorithm in the GraphPad Prism 5.02 software. The data points are means ± SEM (n= 4).