Figure 8.

The effect of cannabinoids on cytokine-induced FD4 flux. (A) CBD (1 µM) or mAEA (100 nM) was applied apically at time zero together with the cytokines (IFNγ and TNFα, 100 ng·mL⁻¹) or after 24 h of cytokine application (basal application). AM251 (100 nM) was applied apically with CBD or mAEA after 24 h cytokine application. (B) AM251 or AM630 (both at 100 nM) were applied apically either with cytokines at time zero or after 24 h of cytokine application. Data are given as means with error bars representing SEM. (n= 3, ***P < 0.001, as compared with vehicle group; ^##P < 0.01, ^###P < 0.001, as compared with cytokine-treated group, anova).