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. Author manuscript; available in PMC: 2013 Sep 1.
Published in final edited form as: J Mol Cell Cardiol. 2012 Jul 13;53(3):437–445. doi: 10.1016/j.yjmcc.2012.07.001

Figure 1. KATP overexpression results in embryonic lethality.

Figure 1

(A) Genotype distribution from breeding of heterozygous STG mice overexpressing either SUR1 line 720 or gain of function Kir6.2(ΔN30, K185Q) line 4. 20 pregnancies were assessed between 9.5–18 dpc (with a total of 166 embryos). Embryonic genotyping distributed as expected from a heterozygous inheritance pattern of each of the single transgenes, with ~ 1/4 of the embryos of each genotype. (B) Embryonic lethality distribution of the different genotypes. Of note, the 15% fraction for DTG (right lower pie), represents embryos that were alive (beating heart) at 9.5–10.5 dpc, none of the DTG was alive at 11.5 dpc. (C) Embryonic lethality per pregnancy from the above crosses (* p<0.05 compared to WT, Line 720 and Line 4). No embryonic lethality was detected in 20 WT embryos. All of the DTG embryos extracted after 11.5 dpc were dead.