Table 2. Biomarker Shedding and Tumor Growth Parameters Used in Sensitivity Analyses.

Parameter values were based on ovarian carcinoma progression and CA125 shedding in the average female patient.

	Parameter	Description (Units)	Baseline Value	Range Simulated	Ref
Shedding by Tumor Cells Only	fPL,T	Fraction of biomarker entering tumor vasculature	0.1	1×10−4 to 1	–
	RT	Biomarker shedding rate per tumor cell (U/day/cell)	4.5×10−5	4.5×10−11 to 0.45	(27)
	NT,0	Initial number of biomarker-shedding tumor cells	1	1 to 1×1010	N/A
	kGR	Growth rate of tumor cell population (day−1)	5.78×10−3	3.46×10−3 to 0.578	(18)
	kEL	Elimination rate of biomarker from plasma (day−1)	0.11	1.10×10−6 to 5.12	(23)
	kdecay	Rate at which tumor growth rate decreases (day−1)	1×10−4	1.29×10−6 to 2.15×10−4	–
	d	Detection limit of assay (U/ml)	1.5	1.5×10−9 to 15	(24, 25, 27)
Shedding by Tumor and Healthy Cells	fPL,T	Fraction of biomarker entering tumor vasculature	0.1	1×10−4 to 1	–
	RT	Biomarker shedding rate per tumor cell (U/day/cell)	4.5×10−5	4.5×10−11 to 0.45	(27)
	NT,0	Initial number of biomarker-shedding tumor cells	1	1 to 1×1010	N/A
	kGR	Growth rate of tumor cell population (day−1)	5.78×10−3	3.46×10−3 to 0.578	(18)
	kEL	Elimination rate of biomarker from plasma (day−1)	0.11	1.10×10−6 to 5.12	(23)
	kdecay	Rate at which tumor growth rate decreases (day−1)	1×10−4	1.29×10−6 to 2.15×10−4	–
	fPL,HRHNH,0	Healthy cell shedding influx1 (U/day)	4.56×103	4.56×10−6 to 4.56×104	(22)
	c	Plasma biomarker “cut-off” for healthy and disease states (U/ml)	34.11	13.6 to 75	(11, 17, 21)

¹Units of individual parameters are as follows: f_PL,H (fraction), R_H (U/day/cell) and N_H,0 (cells).