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A) Representative photographs of the tumor sections examined by immunohistochemical staining for VEGF (×400 magnification). The assessment of VEGF was based on a cytoplasmic staining pattern. B) The tumors were harvested and assayed for VEGF protein by ELISA. The results are presented as mean ± SD (n = 7 tumors). Fucoidan caused significant reduction in intratumoral VEGF expression compared with control group. *P<0.05 vs Control.
