Table 2. The results of a linear mixed model to estimate the effect of closantel treatment at dry-off (or approximately 42 days before calving for heifers) on 305-day milk production in 11 herds exposed to F. hepatica (based on 402 cows).

Variable	β	S.E.	P
Intercept	10,685	544	<0.001
Closantel (vs. placebo)	303	135	0.026
Lactation number (baseline = 3rd and higher):			<0.001
First	−2,522	189
Second	−543	163
Breed (baseline = Holstein Friesian):
Dutch Friesian	−256	259	0.324
Ln (SCCa/1000)	−158	61	0.009

^aSomatic cell count.