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Benzodiazepinedione and Nutlin-2 compounds both target the same regions of space corresponding to the Phe-Trp-Leu motif from p53. Representations of high affinity helix (green) shown relative to: a) wild type helix; b) Nutlin-2; c) Benzodiazepinedione compound. Figures were generated using the matchmaker function from Chimera to superpose hDM2 from PDB code 1T4F to pdb codes: a) 1YCR; b) 1RV1; c) 1T4E.
