Skip to main content
. 2012 Aug 20;7(8):e43553. doi: 10.1371/journal.pone.0043553

Figure 6. Shox2 acts downstream of both Hoxa11 and Hoxd11 as well as of Runx2.

Figure 6

Shox2 in situ hybridization on E14.5 (A–D) and E16.5 (E–H) control (A, E), Hoxa11−/−;d11−/− (B, F), Ulnaless (C, G) and Runx2−/−;Runx3−/− (D, H) forelimbs revealed the absence of its expression in the ulna of both Hox mutants (B, C, F, G, red arrows) and in ulna and radius of Runx2−/−;Runx3−/− mutant mice (D, H, red arrows). However, Shox2 expression was detected in other regions of the analyzed forelimbs (B, C, D, G, yellow arrows). 80x magnification (A–C, E–H), 100x magnification (D); R = radius, U = ulna.