Figure 6. Effect of PF4, collagen type I and IP-10 on calcium (Ca²⁺) handling of hPAECs.

(A) Representative Ca²⁺ recording in hPAECs. Bar graphs show the basal Ca²⁺ levels, store depletion (measured as peak of the Ca²⁺ release) and Ca²⁺influx (measured as mean amplitude of the Ca²⁺ signal when external Ca²⁺ was readmitted) of untreated control cells, and cells treated for 6 h and/or 24 h with, (B) 400 ng/ml of PF4, (C) 100 µg/ml of collagen type I and (D) 600 ng/ml of IP-10 (Number of analyzed cells n = 35–109; * p<0.05, ** p<0.01, *** p<0.001 compared to control untreated cells).