Figure 6. SOD1G93A rats receiving lumbar grafts of human spinal neural stem cells showed transient protection of hindlimb motor function and Hoffmann reflex.
Population analyses of media-treated and cell-grafted animals showed no difference in: disease onset - defined as peak body weight (A), early disease progression - defined as the age at which animals had lost 10% body weight (B), or survival (C). Hindlimb motor function assessed by BBB neurological score (D) showed a significantly better score in hNSCs-grafted animals between ages 135–142 d. Similarly, Hoffman reflex recorded in cell-grafted animals during that time period had significantly higher average amplitudes than those from the media-treated group (E), (* P<0.05).