Table 4. Top Significant SNP-associations with mtDNA Levels in GAIT.
| Gene | SNP | Chr | Sex-specificity | MAF† | beta‡ | P-value* |
| MRPL37 | rs10888838 | 1 | Males | 0.1133 | 0.806 | 4.01e-06(a) |
| RNF144 | rs2140855 | 2 | No | 0.3879 | 0.321 | 1.85e-05(a) |
| RNF144 | rs2056634 | 2 | No | 0.1928 | 0.344 | 3.50E-04(b) |
| RNF144 | rs11682769 | 2 | No | 0.2819 | −0.275 | 4.90E-04(b) |
| FLJ41046 | rs2609101 | 2 | No | 0.2282 | 0.317 | 2.14E-04(b) |
| FLJ41046 | rs2564023 | 2 | No | 0.0692 | −0.454 | 3.40E-04(b) |
| FLJ41046 | rs1880800 | 2 | No | 0.4739 | −0.248 | 3.81e-04(b) |
| FLJ41046 | rs7571496 | 2 | No | 0.3032 | 0.241 | 9.27E-04(b) |
| SOX11 | rs813779 | 2 | No | 0.2315 | −0.323 | 2.97E-04(b) |
| TSSC1 | rs2305491 | 2 | No | 0.0805 | 0.447 | 4.91e-04(b) |
| VENTXP7 | rs2731943 | 3 | Females | 0.2541 | 0.489 | 6.93e-05(b) |
| ZNF659 | rs161196 | 3 | No | 0.0301 | 0.903 | 6.94E-05(b) |
| SATB1 | rs7635386 | 3 | Females | 0.3835 | 0.385 | 9.47e-05(b) |
Chr.: Chromosome.
†
Minimal Allele Frequency of the SNP in our sample.
‡
represents the effect of one copy of the rare allele in mtDNA levels when it is expressed in original scale.
*
P-value of the association with mtDNA levels.
(a)
indicates statistical significance after Bonferroni correction for multiple testing.
(b)
indicates statistical significance after B-H adjustment for multiple testing assuming a 10% of false discovery rate.