Table 2. Association of Myostatin (A55T) genotypes with clinical, biochemical, anthropometric and body composition profiles.

Parameters	A/A (1) (n = 251)	A/T (2) (n = 63)	T/T (3) (n = 21)	p value (1&2)	p value (2&3)	p value (1&3)	p value (1, 2&3)
Age (yrs)	37.5±8.7	38.5±9.9	37.0±6.8	0.4	0.5	0.6	0.6
Body mass index (kg/m2)	26.4±4.4	27.2±3.9	28.3±4.2	0.3	0.7	0.3	0.04
Insulin (µU/ml)	8.7±3.2	8.4±3.0	9.1±2.3	0.7	0.5	0.8	0.2
HOMA	2.1±1.02	2.2±0.98	2.3±0.8	0.7	0.9	0.5	0.5
Circumferences (cm)
Waist	91.4±12.0	93.4±11.5	94.4±10.8	0.2	0.4	0.4	0.3
Hip	95.2±9.7	96.7±8.7	97.2±7.9	0.8	0.5	0.7	0.3
WH-R	0.96±0.09	0.97±0.08	0.97±0.05	0.6	0.6	0.8	0.3
Mid thigh	54.2±10.4	55.3±9.7	56.4±12.2	0.4	0.7	0.5	0.4
Mid arm	27.1±3.3	27.9±3.3	28.1±5.7	0.9	0.6	0.4	0.3
Neck	35.7±4.2	37.1±3.1	33.2±3.1	0.09	0.08	0.2	0.5
Skinfolds thickness (mm)
Biceps	17.0±8.1	17.6±9.4	19.4±7.5	0.7	0.4	0.6	0.2
Triceps	20±9.3	21.1±9.1	21.5±6.4	0.6	0.4	0.4	0.2
Subscapular	39.1±8.6	41.2±8.9	40.1±10.2	0.1	0.3	0.4	0.09
Suprailiac	38.2±13.9	41.3±10.3	45.6±11.5	0.1	0.06	0.04	0.05
Lateral thoracic	39.3±11.2	40.4±12.3	41.1±9.5	0.5	0.7	0.9	0.2
TSF	101.1±30.6	104.1±30.9	126.7±24.9	0.06	0.009	0.001	0.008
Dual Energy X-ray Absorptiometry
Body fat (%)	35.1±6.7	36.3±8.8	45.2±9.8	0.4	0.02	0.001	0.002
Body fat (%)	35.1±6.7	36.3±8.8	45.2±9.8	0.4	0.02	0.001	0.002
Total lean mass (%)	72.2±12.3	65.2±11.8	51.9±10.8	0.02	0.01	0.002	0.03
Total lean mass (kg)	49.6±8.2	46.8±7.7	45.6±9.6	0.6	0.7	0.06	0.04
Total BMD (g cm−2)	1.21±0.15	1.21±0.08	1.23±0.09	0.9	0.6	0.6	0.8

All values are given as mean ± standard deviation; n, number of subjects. Due to multiple comparisons within each genotype, a Bonferroni correction was applied. Statistical significance was established at a P value of 0.05. HOMA-homoeostasis model assessment; WH-R, Waist-to-hip ratio; TSF, total skinfolds (sum of four skinfold thickness); BMD, bone mineral density.