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. 2012 Aug 20;7(8):e43023. doi: 10.1371/journal.pone.0043023

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© 2012 Li et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) Computational model illustrated docking of compound 16 at the active site of rat NAAA. (B) Effect of mutant Ala²⁰⁹-NAAA on NAAA activity. Mock, HEK293 cell heterogeneously overexpressing vector control; NAAA, HEK293 cell heterogeneously overexpressing NAAA; Ala209, HEK293 cell heterogeneously overexpressing mutant Ala²⁰⁹-NAAA. ***, P<0.001 vs. NAAA, n = 5.