Table 5B.

Combination Therapies – Gait Training + Pharmacological Agents

Articles	Methods	Results
Fung et al 1990 Canada D&B=10 pre-post	2 males, age 23–26 yrs, incomplete SCI, C7-T4, 8–11 months post-injury. combined cyproheptadine and clonidine + BWSTT (manual): 1–2 hours, 3–5 times/wk, 3–8 wks. Outcome measures: gait speed	Both subjects wheelchair-bound pre- treatment. Following medication and training, both subjects could walk overground with ambulatory aids (crutches or walker) at 0.1–0.2 m/s.
Walker & Harris 1993 USA PEDro=8 N=9 RCT	9 males & females, age 21–44 yrs, incomplete SCI, C5-L1, 1–13 yrs post-injury. Treatment: Double-blind, placebo-controlled crossover study design: Intravenous GM-1 ganglioside (Sygen®) or placebo + 2 hours PT (gait training) 6X/wk for 2 months, followed by switch of drug administration (total 4 months). All subjects given 6 months of PT before trial. Outcome measures: motor score, walking distance and velocity.	GM-1 + PT resulted in ↑ motor scores, walking distance, and walking velocity. Effects of GM-1 persisted in subjects who were given GM-1 before placebo.