Figure 1.

Endogenous IL-5 is protective in cecal ligation and puncture (CLP) sepsis. (A) Survival curve of IL-5^−/− or wild-type (WT) C57Bl/6 controls after sublethal CLP. Data were analyzed using the log-rank test. n = 5–10 per group. (B and C) Wild-type C57Bl/6 and IL-5^−/− were killed 18 hours after CLP for analysis. Bars represent the mean ± SEM. n = 5 per group. (B) Evans Blue dye leak measured by optical density, shown as the ratio of dye in the lung to plasma. (C) Bacterial burden measured by serial dilution and (D) IL-6, IL-10, and IL-12 measured by ELISA in the blood (upper panel) and peritoneal lavage fluid (lower panel). Data were analyzed by Student t test; significance is defined as *P < 0.05.