Table 3.

BOLD Response During Novel Verbal Encoding in Each Group for Regions of Significant Binge × Marijuana Interactions and the Hippocampal a Priori Region of Interest

Anatomic Region	Brodmann Areas	Volume (μl)	Talairach Coordinates			Activation Mean (SD)				Effect Size Partial η2
			x	y	z	CON (n = 22)	BD (n = 16)	MJ (n = 8)	BD+MJ (n = 28)
Significant Interaction Clusters
Left superior/middle frontal gyri b,c	6, 8	3996	29	−20	51	0.37 (1.37)	5.39 (1.60)	7.96 (2.27)	0.48 (1.21)	0.17
Right inferior/middle frontal gyri a,b,c	10, 45	3645	−44	−41	−1	−1.88 (1.41)	4.41 (1.65)	6.39 (2.33)	−0.76 (1.25)	0.18
Right superior/middle frontal gyri a,b	6, 8	3159	−26	−26	54	−4.79 (1.11)	0.90 (1.31)	2.08 (1.85)	−2.58 (0.99)	0.17
Medial cuneus/lingual gyrus a,b,d	18	2700	2	89	9	7.48(2.25)	−7.20(2.64)	−5.25 (3.74)	1.93(2.00)	0.19
Hippocampal Regions of Interest
Left hippocampus  BOLD Response						2.52(2.60)*	1.67(2.08)*	0.82 (3.09)	2.60(3.23)*
Left hippocampus  Effect Size Cohen’s d						1.37	1.14	0.38	1.14
Right hippocampus  BOLD Response						1.57(2.42)*	1.50(2.34)*	1.00 (2.64)	1.56(2.80)*
Right hippocampus  Effect Size Cohen’s d						0.92	0.91	0.54	0.79

Note: Coordinates refer to maximum signal intensity group difference within cluster. Mean activations represent average fit coefficients within each cluster, positive values indicate greater response during encoding than fixation. Partial η² refers to effect sizes for interaction within the cluster; Cohen’s d refers to effect sizes for single sample t-tests within hippocampal regions of interest.

^aCON significantly different from BD (Tukey α = .05)

^bCON significantly different from MJ (Tukey α = .05)

^cMJ significantly different from BD+MJ (Tukey α = .05)

^dBD significantly different from BD+MJ (Tukey α = .05)

^*Novel verbal encoding activation significantly different from zero (p < .01)