TABLE 1.

GENES WITH NONSYNONYMOUS SINGLE-NUCLEOTIDE POLYMORPHISMS ASSOCIATED WITH CHLORINE SURVIVAL TIME

Name of Gene	Chromosome	Position (Base Pairs)	Association dbSNP	−log(P)	Nonsynonymous dbSNP	Exon	Amino Acid Substitution	Phenotype (%)	Allele Frequency
Tns1	1	72920639	rs3021883	4.1	rs40124058	19	L944V	20.1	30.5
					rs36340401	35	N1882S	20.3	30.5
Slco4c1	1	98701146	rs13476000	5.6	rs37471241	13	T707A	16.3	37.6
Ikbkap	4	56426555	rs32078659	4.8	rs27869828	11	I345V	11.3	24.5
					rs27869847	18	G662V	11.3	24.5
					rs27835086	36	A1309V	17.7	23.4
Ncor2	5	125502713	rs33262018	4.2	rs36571333	44	T2229A	14.4	24.2
Aacs	5	125996775	rs29541719	4.6	rs38516850	1	Q5R	20.0	28.1
					rs36769124	9	T321I	20.0	28.1
Fry	5	151155327	rs3684936	4.1	rs50343365	22	T2568A	13.5	19.1
Cyp11a1	9	58075842	rs3674363	5.0	rs47078233	9	N522D	13.7	14.1
Ttk	9	84014785	rs30022241	4.9	rs33070516	9	*302L	11.6	47.8
					rs33070518	9	T306P	11.6	47.8
Tnfrsf19	14	61611931	rs30388803	4.4	rs37583013	9	T342A	14.4	40.0
					rs37057546	9	N286D	14.4	40.0
Slc38a4	15	96687641	rs32255071	6.3	rs46306226	16	N544S	12.6	17.9
Slc35a5	16	45150868	rs4180445	4.1	rs32739736	6	H403R	12.0	48.1

Definition of abbreviations: Tns1, tensin 1; Slco4c1, solute carrier organic anion transporter family, member 4C1; IkbKap, inhibitor of kappa light polypeptide enhancer in B cells; Ncor2, nuclear receptor co-repressor 2; Aacs, acetoacetyl coenzyme A synthetase; Fry, furry homolog; Cyp11a1, cytochrome P₄₅₀ family 11, subfamily A, polypeptide 1; Ttk, Ttk protein kinase; Tnfrsf19, tumor necrosis factor receptor superfamily, member 19; Slc38a4, solute carrier family 38, member 4; Slc35a5, solute carrier family 35, member 5; dbSNP, Single Nucleotide Polymorphism Database at NCBI; rs number, dbSNP reference sequence.