Table 5.
Cumulative Effect of Risk and Protective Classical HLA Alleles for PBC Susceptibility
| Categorya | Controls Number (%)b |
Cases Number (%) |
Odds Ratio | p-value |
|---|---|---|---|---|
| RISK - PROTECTIVE =/< −2 | 177 (12.3) | 34 (5.0) | 0.38 | 5.87E-08 |
| RISK - PROTECTIVE =/< −1 | 682 (48.1) | 185 (27.4) | 0.50 | 2.03E-12 |
| RISK - PROTECTIVE = 0 | 522 (36.3) | 246 (36.4) | 1.00 | NS |
| RISK - PROTECTIVE =/> +1 | 226 (15.7) | 245 (36.2) | 3.05 | 6.94E-25 |
| RISK - PRPTECTIVE =/> 2 | 32 (2.2) | 72 (10.7) | 5.25 | 1.37E-15 |
a
This table shows the results of categorizing each participant based on the sum of the each risk allele (positive number) and each protective allele (negative number). The risk alleles are DRB1*08, DRB1*14 and DPB1*03:01. The protective alleles are DRB1*11 and DRB1*13. The alleles were determined from the most probable allele after imputation and haplotype analyses (see Methods).
b
The number of subjects that are in each category are shown together with the % of total controls (1440) or percent of cases (676).
c
The two tailed Fisher exact p value from contingency table analyses comparing cases and controls in each category.