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. Author manuscript; available in PMC: 2013 Sep 1.
Published in final edited form as: J Bone Miner Res. 2012 Sep;27(9):2001–2014. doi: 10.1002/jbmr.1663

Figure 7. A schematic diagram showing the proposed actions of PTH on enhanced BMP-Smad signaling.

Figure 7

In bone growth and development, BMP activity is controlled tightly by many antagonists spatially and temporally. With PTH treatment, a PTH1R/LRP6 complex is formed and its endocytosis results in increased binding affinity of BMP to its receptor, which promotes BMP-Smad signaling and MSCs differentiation.