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. Author manuscript; available in PMC: 2013 Sep 1.
Published in final edited form as: J Bone Miner Res. 2012 Sep;27(9):1927–1935. doi: 10.1002/jbmr.1657

Table 1.

Relationship between predicted strength and bone volume fraction for the three cavity-placement schemes per specimen.

Canine vertebra
(n=10)
Human vertebra
(n=16)
Human femoral neck
(n=14)

Sy = m (BV/TV) + b Sy = m (BV/TV) + b Sy = m (BV/TV) + b

Cavity placement m b m b m b
None 117.1a (36.5) −13.0 (8.3) 25.1a (6.8) −0.97 (0.79) 100.9a (15.9) −9.1 (3.7)
Random 107.8a (30.6) −12.2 (6.5) 23.0a (6.1) −0.89 (0.67) 92.6a (15.1) −8.2 (3.3)
High-strain 92.8a (34.9) −11.2 (7.5) 18.1a (5.9) −0.77 (0.65) 81.7a (15.4) −8.6 (3.4)

Data shows parameter estimate means (± 95% confidence interval) from linear regression. Strength has units of MPa (106 N/m2). Multiple comparisons performed using the Bonferroni adjustment. n denotes the number of bone specimens per group; each specimen was analyzed assuming three different types of cavity placement.

a

p<0.01 vs. both other cavity-placement schemes.