Table 1.
The integrin αvβ3 binding of 1 and 2 traced by 125I-c(RGDyK).
| Compound | IC50 (nM, Mean ± SD) |
Ki (Mean ± SD) | R2 |
|---|---|---|---|
| 1 | 0.281 ± 0.009 | 0.043 ± 0.015 | 0.957 |
| 2 | 4.305 ± 0.056 | 0.663 ± 0.086 | 0.9874 |
| c(RGDyK) | 3.52 ± 0.354 | 2.27 ± 0.228 | 0.9957 |
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