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. Author manuscript; available in PMC: 2013 Mar 1.
Published in final edited form as: J Invest Dermatol. 2012 May 24;132(9):2158–2165. doi: 10.1038/jid.2012.144

Figure 6. Suppression of TRPV3-mediated increase of CREB transcriptional activity by Mg2+.

Figure 6

(a) The CRE-Luc activity in control groups is set to 100% for a and b, and treated groups are normalized to this value (mean ± s.e.m. from 15 animals). Summarized data showing TRPV3 agonist cocktail-induced CRE-Luc activity in the absence or presence of ruthenium red (RR) in transgenic mouse keratinocytes as well as transgenic mouse keratinocytes transfected with TRPV3 siRNA and control siRNA. * p<0.05 compared with control; # p < 0.05. (b) TRPV3 agonist cocktail-induced CRE-Luc activity in the absence or presence or different concentrations of Mg2+ in keratinocytes from transgenic mice. * p<0.05.