Fig. 1. Adenoviral protein V regulates subcellular localization of NPM1 during infection.
HPAEC cells were infected with adenovirus at an MOI of 10 PFU/cell for various times, followed by immunofluorescent staining. Subcellular localization of adenoviral pV and endogenous NPM1 was observed in infected cells at various times post-infection. Viral and endogenous cellular proteins in infected cells were visualized by staining with anti-pV and anti-NPM1 followed by secondary antibody conjugated with fluorescent probes. Uninfected and infected cells were stained for nuclear DNA using Hoechst 33342 and fluorescent signals were visualized by epifluorescence microscopy.