Figure 1. Deletion of Sin3A in male germ cells results in Sertoli cell only phenotype.

(a.) Representative testes from adult (24-week old) Sin3A^gc+/− and Sin3A^gc−/− male mice. (b.) Weights (mg) of the testes from Sin3A^gc+/− (black) and Sin3A^gc−/− males (grey) at day 10 (D10, n=3 for each genotype, p<0.028), D14 (n=3, p<0.01), D21 day (n=6, p<0.008), adult (n=3, p<0.007). Error bars represent the standard deviation (c.) Representative Hematoxylin and eosin-stained cross sections of testes from D10, D14 and D21 and adult Sin3A^gc+/− (left) or Sin3A^gc−/− mice (right). Scale bar =50μm. (d.) Representative immunostaining with an anti-Sin3A antibody on cross sections from D10, D14, D21 and adult testis of the indicated genotype. Scale bar =50μm. Inset boxes correspond to higher magnification.