. Author manuscript; available in PMC: 2013 Sep 1.

Published in final edited form as: Bioorg Med Chem Lett. 2012 Jul 20;22(17):5460–5465. doi: 10.1016/j.bmcl.2012.07.043

Table 2.

Enzyme inhibitory and cellular activity of inhibitors

Entry	Inhibitor	k_i (nM)	IC₅₀(nM)^a,^b
1.	4a	1463	nt
2.	4b	79	390
3.	4c	104	nt
4.	4d	106	nt
5.	4e	144	nt
6.	4f	13	21
7.	4g	11	23
8.	4h	23	48
9.	4i	39	51

IC₅₀ was determined in neuroblastoma cells.

GRL-8234 exhibited K_i; = 1.8 nM, IC₅₀ = 2.5 nM in this assay.^9a