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. Author manuscript; available in PMC: 2013 Aug 17.
Published in final edited form as: ACS Chem Biol. 2012 Jun 12;7(8):1454–1461. doi: 10.1021/cb300174c

Figure 3.

Figure 3

Normalized RNAi activity data for siR-A series. A-00 corresponds to the unmodified siRNA duplex. Data are averages and s.d. of three independent experiments. HeLa cells were co-transfected with 2 pmol (3.33 nM), 20 pmol (33.3 nM) or 100 pmol (166 nM) of siRNA duplex. Decreased firefly luciferase signal indicates enhanced RNAi activity. All control experiments were conducted in an identical manner (wells contained HeLa cells treated with firefly and Renilla luciferase plasmids in the absence of siRNA).