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. 2012 Jul 13;153(9):4491–4501. doi: 10.1210/en.2012-1003

Fig. 5.

Fig. 5.

Effect of FGF9 (10 ng/ml) on steroidogenic enzyme, FSHR and StAR gene expression in GC of small and large follicles (experiment 4). A, Lack of effect of FGF9 on CYP19A1 (aromatase) mRNA abundance; B, inhibitory effect of FGF9 on CYP11A1 (side-chain cleavage enzyme) mRNA abundance; C, lack of effect of FGF9 on StAR mRNA abundance in SMGC and LGGC; D, inhibitory effect of FGF9 on FSHR mRNA abundance in SMGC and LGGC. *, Within a panel, mean differs from its respective control (P < 0.05). GC from small and large follicles were cultured for 48 h in the presence of 10% FCS and then treated with FGF9 for 24 h. All cells were concomitantly treated with 100 ng/ml IGF-I and 30 ng/ml FSH. Values are means of three separate experiments (± sem) and normalized to constitutively expressed 18S rRNA.